Flow cytometric analysis of Human CD181 expression on human peripheral blood Leukocytes. Human peripheral blood Leukocytes were stained with either Alexa Fluor® 488 Mouse IgG2b, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD181 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Mouse Anti-Human CD181 Antibody (S-3490)
Alexa Fluor® 488 Mouse Anti-Human CD181 Antibody (S-3490)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD181 |
| Synonyms | C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; CDw128a; High affinity interleukin-8 receptor A (IL-8R A); IL-8 receptor type 1; CMKAR1; IL8RA; CXCR1 |
| Location | Cell membrane |
| Accession | P25024 |
| Clone Number | S-3490 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD181, also known as CXCR1, is a 67–70 kDa G-protein-coupled receptor that selectively binds the chemokine interleukin-8 (IL-8) and mediates rapid neutrophil activation, chemotaxis and respiratory burst through Gαi-triggered calcium flux and phospholipase D signaling; expressed on granulocytes, NK cells, monocytes, endothelial cells and oligodendrocytes, it functions as a homodimer or heterodimer with CD182 (CXCR2), and its sustained up-regulation has been implicated in systemic lupus erythematosus-associated hemolytic anemia and other inflammatory disorders.
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