Drug Discovery

Reagents spanning the drug discovery workflow, from therapeutic target protein to functional readout, combining recombinant target proteins, GPCR stable cell lines, TR-FRET binding and signalling kits, organoid culture systems, and the ELISA, ELISpot, HICA and luciferase assays used to quantify a response.

Target proteins cover small-molecule targets such as KIF18A, PDGFR alpha and the CRBN/DDB1 complex, membrane proteins in nanodisc or detergent, and fluorescently labelled antigens for CAR-T development. GPCR stable cell lines are offered in CHO-K1 and HEK293 backgrounds across human, mouse and rat receptors.

Selection follows the stage of the project: a defined protein for binding or structural work, a cell line when the target has to be studied in a signalling context, an organoid when a three-dimensional model is required, and a homogeneous assay when throughput matters.