Fumaroylation: A New Hub Linking Metabolism and Epigenetics

1. Concept

Protein lysine fumaroylation is a novel posttranslational acylation modification where fumaroyl groups from TCA cycle intermediate fumarate are covalently attached to lysine residues. It acts as a molecular sensor linking cellular energy status to chromatin state and gene transcription.

2. Research Frontier

Fumaroylation has emerged as a key node in metabolism–epigenetics crosstalk. Unlike classic acetylation and methylation, fumaroylation directly transmits metabolic signals to chromatin. Its writers, erasers and readers are being rapidly identified, with SIRT5 confirmed as a major defumaroylase.

3. Research Significance

· Fumaroylation neutralizes histone positive charge, relaxes chromatin and promotes gene transcription.

· It mediates adaptive responses to hypoxia, nutrient deprivation and oxidative stress.

· Dysregulation is associated with cancer, ischemia–reperfusion injury, kidney disease and inflammation.

· It serves as a potential biomarker and drug target for metabolic diseases.

4. Mechanism and Application

· Regulation system: p300/CBP may function as fumaroyltransferases; SIRT5 is a defumaroylase.

· Biological function: Promotes chromatin relaxation and transcriptional activation; mediates metabolic stress adaptation.

· Research methods: WB, IF, IHC, IP, modificationspecific mass spectrometry.

· Product application: Panfumaroylation antibodies enable specific detection and enrichment of fumaroylated proteins.

5. Brand Mission

ANT BIO PTE. LTD. is a professional life science reagent company supplying antibodies, proteins, kits and general reagents. Our subbrands Absin (general reagents & kits), Starter (antibodies) and UA (recombinant proteins) support global research in epigenetics, metabolism and disease.

6. Related Product List

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs

At ANTBIO, we are committed to advancing life science research through highquality, reliable reagents and comprehensive solutions. Our specialized subbrands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customercentricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.