DNA Methylation: The Core of Epigenetic Research

1. Concept

DNA methylation is a stable epigenetic modification that adds methyl groups to the 5carbon of cytosine (forming 5mC), mostly at CpG sites, without altering DNA sequence. It stably regulates gene expression and is inheritable during cell division.

2. Research Frontier

DNA methylation is the most studied epigenetic marker. Singlebase resolution sequencing, highthroughput arrays and oxidative bisulfite sequencing enable precise profiling of 5mC and its oxidative derivatives. Dynamic reprogramming occurs in development, differentiation and tumorigenesis.

3. Research Significance

· Governs embryonic development, cell fate, genomic imprinting and Xchromosome inactivation.

· Maintains cell identity and genome stability.

· Aberrant methylation is a hallmark of cancer and correlates with neuropsychiatric, autoimmune and metabolic diseases.

· Circulating cellfree DNA methylation is a promising liquid biopsy biomarker for early cancer detection.

4. Mechanism and Application

· Regulation: Directly blocks transcription factors; recruits methylbinding proteins and repressive complexes.

· Detection technologies: Bisulfite conversion, methylation arrays, WGBS, RRBS, oxBSSeq, MSP.

· Product application: Sitespecific histone methylation antibodies support epigenetic and chromatin state analysis.

5. Brand Mission

ANT BIO PTE. LTD. is a trusted life science reagent provider focusing on antibodies, proteins, kits and general reagents. Our subbrands Absin (general reagents & kits), Starter (antibodies) and UA (recombinant proteins) empower epigenetic research, disease diagnosis and drug development.

6. Related Product List

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs

At ANTBIO, we are committed to advancing life science research through highquality, reliable reagents and comprehensive solutions. Our specialized subbrands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customercentricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.