1μg (R: reducing condition, N: non-reducing condition).
ZNRF3 Fc Chimera Protein, Human
ZNRF3 Fc Chimera Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | ZNRF3, Zinc, RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203 |
| Accession | Q9ULT6-1 |
| Amino Acid Sequence | Lys56-Met219 with Human IgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 45-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.SwissProt Accession # Q9ULT6. |
Background
ZNRF3 (zinc/RING finger protein 3), also known as RNF203, is a predicted 101kDa type I transmembrane protein and a member of the ZNRF3 family of ubiquitin ligases. This protein is specifically expressed in stem cells located at the base of colon crypts, where it restricts the proliferative effects of Wnts proteins. ZNRF3 is also found in normal gastric tissues; however, its expression is downregulated in gastric adenocarcinomas.
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SDS-PAGE
SEC-HPLC
The purity of ZNRF3 Fc Chimera Protein, Human is greater than 90% as determined by SEC-HPLC.
ELISA
Immobilized RSPO3 His Tag, Human (Cat. No. UA040025) at 2.0μg/mL (100μL/well) can bind ZNRF3 Fc Chimera Protein, Human (Cat. No. UA011119) with EC50 of 1.59-3.16 ng/mL.
