ZNF217 Recombinant Rabbit mAb (S-4699-14)

ZNF217 protein (Zinc Finger Protein 217) is a member of the Krüppel-type C2H2 zinc finger transcription factor family, functioning as a potential oncogene in various tumors. Its C-terminus contains multiple C2H2-type zinc finger domains responsible for mediating specific binding to target gene DNA sequences, while the N-terminal SCAN domain mediates homo- or hetero-oligomerization between proteins and regulates its transcriptional activity. Functionally, ZNF217 participates in key processes such as cell cycle regulation, apoptosis, and epithelial-mesenchymal transition primarily through transcriptional regulation. Its most classic mechanism is repressing the transcription of tumor suppressor genes including CDKN1A/p21 and CDKN2A/p14ARF, thereby promoting cell proliferation and conferring resistance to apoptosis. In the oncology field, ZNF217 is considered a marker of poor prognosis; its gene copy number amplification or upregulated expression is commonly observed in multiple malignancies including ovarian cancer, breast cancer, colorectal cancer, and hepatocellular carcinoma, and is closely associated with chemoresistance, tumor invasion, and enhanced metastatic capacity. Furthermore, ZNF217 also interacts with hormone receptor signaling and participates in regulating estrogen receptor α expression, suggesting that it may exert additional pathological roles in hormone-dependent tumors.