VEGF165 Recombinant Rabbit mAb (SDT-3855-2)
VEGF165 Recombinant Rabbit mAb (SDT-3855-2)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | VEGF-A |
| Synonyms | Vascular endothelial growth factor A, long form; L-VEGF; Vascular permeability factor (VPF); VEGF; VEGFA |
| Immunogen | Recombinant Protein |
| Clone Number | SDT-3855-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu, Ms |
| Predicted Reactivity | Rt |
| Cross Reactivity | It shows good reactivity with VEGF121 and no cross reactivity against Human TNF-α. |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | ＞95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Vascular Endothelial Growth Factor A (VEGFA) is a pivotal biomarker in clinical diagnosis, primarily valued for its central role in angiogenesis and disease progression. As a key regulator of new blood vessel formation, its expression is frequently dysregulated in numerous pathologies, especially solid tumors.
In oncology, elevated VEGFA levels in serum or tumor tissues strongly correlate with tumor growth, metastasis, and poor prognosis, making it a critical prognostic indicator. For example, in non-small cell lung cancer, VEGFA expression helps predict disease progression and assess patient outcomes. Beyond diagnosis, it serves as a predictive biomarker for anti-angiogenic therapies, such as bevacizumab, enabling personalized treatment strategies.
Moreover, VEGFA’s diagnostic significance extends to non-neoplastic conditions, including cardiovascular diseases, diabetic retinopathy, and inflammatory disorders, where aberrant angiogenesis contributes to pathogenesis. Its detection, via immunohistochemistry or liquid biopsies, offers a minimally invasive means of disease monitoring. In summary, VEGFA is an indispensable tool in clinical diagnostics, linking disease detection, prognosis, and therapeutic guidance.
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