1μg (R: reducing condition, N: non-reducing condition).
VEGF R2/Flk-1/KDR His Tag Protein, Rhesus macaque
VEGF R2/Flk-1/KDR His Tag Protein, Rhesus macaque
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Product Details
Product Details
Product Specification
| Species | Rhesus macaque |
| Synonyms | KDR,CD309,FLK1,VEGFR,VEGFR2 |
| Accession | F7E313 |
| Amino Acid Sequence | Ala20-Glu764, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 100-130kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Lian, L. et al. (2019) BMC Cancer. 19:183. |
Background
Vascular endothelial Growth Factor Receptor 2 (VEGFR2), also known as FLK-1, KDR, and CD309, is a type I single-pass membrane receptor，and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). Mature VEGFR2 contains a 745 amino acid extracelluar domain with seven immunoglobulin-like repeats, 21 transmembrane domain and 571 cytoplasmic domain. Within the extracellular domain, human VEGFR2 shares 80% homology with that of mouse and rat. VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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SDS-PAGE
SEC-HPLC
The purity of VEGF R2/Flk-1/KDR His Tag Protein, Rhesus macaque is greater than 95% as determined by SEC-HPLC.
ELISA
Immobilized VEGF R2/Flk-1/KDR His Tag Protein, Rhesus macaque (Cat. No. UA010877) at 2μg/mL (100μL/well) can bind Olinvacimab (Cat. No. UA011020) with EC50 of 3.11-3.93 ng/ml.
Immobilized VEGF R2/Flk-1/KDR His Tag Protein, Rhesus macaque (Cat. No. UA010877) at 2.0μg/mL (100μL/well) can bind Olinvacimab (Cat. No. UA011020) with EC50 of 3.11-3.93ng/mL.
