TSH Recombinant Rabbit mAb (SDT-1595-58)
TSH Recombinant Rabbit mAb (SDT-1595-58)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | TSH |
| Synonyms | TSH (Thyroid-Stimulating Hormone) |
| Immunogen | Recombinant Protein |
| Clone Number | SDT-1595-58 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Recognize TSH heterodimer but no cross reactivity against TSH α subunit and LH, FSH, hGH, hCG. |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Thyroid-stimulating hormone (TSH) is a 28 kDa heterodimeric glycoprotein secreted by the anterior pituitary, composed of a common α-subunit (92 amino acids shared with LH, FSH, and hCG) and a unique β-subunit (118 amino acids) that confers specificity; it binds to the Gs-coupled TSH receptor on thyroid follicular cells to activate adenylyl cyclase, up-regulate iodine uptake, thyroglobulin iodination, and proteolysis, thereby stimulating synthesis and release of thyroxine (T4) and triiodothyronine (T3), and its circulating level is regulated by negative feedback from free T4/T3 and by hypothalamic TRH, making TSH the central sensor and effector of the hypothalamic–pituitary–thyroid axis. Therefore, TSH in the blood is a sensitive test reflecting the function of the hypothalamic-pituitary-thyroid axis, especially significant for the diagnosis of subclinical hyperthyroidism and subclinical hypothyroidism.
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