1μg (R: reducing condition, N: non-reducing condition).
TPBG/5T4 Fc Chimera Protein, Mouse
TPBG/5T4 Fc Chimera Protein, Mouse
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$256 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | TPBG,5T4, M6P1,5T4AG, WAIF1, 5T4 oncofetal antigen, Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein |
| Accession | Q9Z0L0 |
| Amino Acid Sequence | Ser32-Ser361 with Human IgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 72-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Kagermeier-Schenk, B. et al. (2011) Dev. Cell. 21:1129. |
Background
5T4, also known as Trophoblast glycoprotein and Wnt-activated inhibitory factor 1 (WAIF1), is a single-pass transmembrane protein which may function as an inhibitor of Wnt/beta-catenin signaling. It has been identified that TIP-2/GIPC, a common interacting protein involved in cancer, interacts with 5T4 through its PDZ domain. 5T4 inhibits Wnt/ beta -catenin signaling by binding to LRP6 and inhibit Wnt-induced LRP6 internalization into endocytic vesicles. Conversely, 5T4 can activate noncanonical Wnt signaling through DKK1. In addition to LRP6, in-house data indicates 5T4 can also interact with Frizzled8.
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SDS-PAGE
SEC-HPLC
The purity of TPBG/5T4 Fc Chimera Protein, Mouse is greater than 95% as determined by SEC-HPLC.
