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TPBG/5T4 Fc Chimera Protein, Human

TPBG/5T4 Fc Chimera Protein, Human

Catalog Number: UA016153 Brand: UA BIOSCIENCE
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$215 USD
$215 USD
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Product Details

Product Specification


Species Human
Accession Q13641
Amino Acid Sequence

Ser32-Ser355 with hIgG1 Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight 50-72kDa (Reducing)
Purity ＞95% by SDS-PAGE,＞90% by HPLC
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.  

· Please avoid repeated freeze-thaw cycles.
Reference

1.Li F, Wang Y, Cao J, Chen Q, Gao Y, Li R, Yuan L. Integrated analysis of genes shared between type 2 diabetes mellitus and osteoporosis. Front Pharmacol. 2024 Jun 20; 15:1388205.
2.Jiang, Yq., Ma, Xj., Wang, Ym. et al. Human germline-like monoclonal antibody against 5T4 enables potent ADC and CAR-T therapies for solid tumors. Acta Pharmacol Sin 47, 1326–1337 (2026).

Background

Trophoblast glycoprotein (TPBG), also known as 5T4, is a therapeutic target for several anticancer agents in clinical development. This is primarily due to its high expression in tumors and low expression in normal adult tissues. The TPBG gene encodes a leucine-rich transmembrane glycoprotein that may play a role in cell adhesion. TPBG is expressed by all types of trophoblasts as early as the ninth week of development.

Picture

SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of TPBG/5T4 Fc Chimera Protein, Human is more than 90% determined by SEC-HPLC.

ELISA

Immobilized TPBG/5T4 Fc Chimera Protein, Human (Cat. No.UA016153) at 1.0μg/mL (100μL/well) can bind Naptumomab with EC50 of 22.0-33.0ng/mL.

Immobilized TPBG/5T4 Fc Chimera Protein, Human (Cat. No.UA016153) at 1.0μg/mL (100μL/well) can bind TPBG Recombinant Monoclonal Antibody with EC50 of 0.41-1.70ng/mL.