TIMP-1 Protein, Human

Catalog Number: UA040241 Brand: UA BIOSCIENCE

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$236 USD

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Product Details

Product Specification

Species	Human
Synonyms	CLGI,Collagenase inhibitor,collagenase inhibitor),EPATIMP-1,EPO,erythroid potentiating activity,Erythroid-potentiating activity,Fibroblast collagenase inhibitor,FLJ90373,HCI,metalloproteinase inhibitor 1,TIMP metallopeptidase inhibitor 1,TIMP1,TIMP-1,TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity,Tissue inhibitor of metalloproteinases 1
Accession	P01033
Amino Acid Sequence	Cys24-Ala207, with C-terminal His Tag
Expression System	HEK293
Molecular Weight	33 kDa (Reducing)
Purity	＞95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized powder
Storage Buffer	PBS, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Hornebeck W. (2004) Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. Pathol Biol. 51(10): 569-573. 2、Soini Y. et al. (2001) Expression of MMP2, MMP9, MT1-MMP, TIMP-1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol. 194(2): 225-231.

Background

TIMP metallopeptidase inhibitor 1 is also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. TIMP1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. Tissue inhibitor matrix metalloproteinase 1 (TIMP1), which belongs to TIMP gene family, is a natural inhibitor of the matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients. Using TIMP1-competent and TIMP1-deficient PC mouse models, we established a causal role of TIMP1 in determining shortened survival and increased liver metastasis in males.