Thrombopoietin Recombinant Rabbit mAb (SDT-386-85)
Thrombopoietin Recombinant Rabbit mAb (SDT-386-85)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Thrombopoietin |
| Immunogen | Recombinant Protein |
| Accession | P40225 |
| Clone Number | SDT-386-85 |
| Antibody Type | Rabbit mAb |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize CD16b |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A |
Background
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. It has been reported that blood trombopoietin (TPO) levels can discriminate between thrombocytopenia due to increased platelet destruction and decreased platelet production. Patients with depressed platelet production had elevated levels of circulating TPO, whereas the TPO levels in patients with an immune-mediated thrombocytopenia were mostly within the normal range. Therefore, measurement of plasma TPO levels provides valuable diagnostic information for the analysis of thrombocytopenia in general.
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