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TGF-β2 Protein, Mouse

TGF-β2 Protein, Mouse

Catalog Number: UA040598 Brand: UA BIOSCIENCE
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$160 USD
$160 USD
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Product Details

Product Specification


Species Mouse
Synonyms Transforming growth factor beta-2, TGF-beta-2, TGF-β2
Accession P27090
Amino Acid Sequence

Ala303-Ser414
Expression System CHO
Molecular Weight

10-12 kDa (Reducing)
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized Powder
Storage Buffer

4mM HCl
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in Reconstitution Buffer after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

·3 months, -20 to -80℃ under sterile conditions after reconstitution.

·1 week, 2 to 8℃ under sterile conditions after reconstitution.

·Please avoid repeated freeze-thaw cycles.
Reference

Science Translational Medicine. 2021;13(605):eabe0407.

Cancer Immunology, Immunotherapy. 2022;71(9):2213-2226.

Background

Transforming Growth Factor-β2 (TGF-β2) is a secreted homodimeric cytokine belonging to the TGF-β superfamily, encoded by the Tgfb2 gene in mice. Among the three mammalian TGF-β isoforms, TGF-β2 exhibits distinctive biological properties, most notably its unique activation mechanism that does not rely on the classical integrin-binding RGD motif present in TGF-β1 and TGF-β3, but instead requires covalent linkage to immobilized matrix or cell-surface molecules. In mouse development, TGF-β2 is indispensable; Tgfb2-null mice exhibit perinatal lethality with a broad spectrum of defects encompassing cardiac, pulmonary, craniofacial, limb, ocular, and urogenital systems.

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Bioactivity

Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. The expected IC50 for this effect is 0.26-0.36ng/ml.

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).