2μg
(R: reducing condition, N: non-reducing condition).
TEAD3 His Tag Protein, Human
TEAD3 His Tag Protein, Human
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$228 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | DTEF1,ETFR 1,ETFR 1,TEAD5,TEF 5 |
| Accession | Q99594 |
| Amino Acid Sequence | Arg218-Asp435, with N-8*HIS |
| Expression System | E.coli |
| Molecular Weight | 27kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 20mTris, 300mNaCl, 20% glycerol, 5mM DTT, pH8.0 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Yi Jin 1, Angela F Messmer-Blust（2011）Trends Cardiovasc Med.21:1 |
Background
The transcriptional enhancer factor (TEF)multigene family is primarily functional in muscle-specific genes throughbinding to MCAT elements that activate or repress transcription of many genesin response to physiological and pathological stimuli. Among the TEF family,TEF-1, RTEF-1, and DTEF-1 are critical regulators of cardiac and smoothmuscle-specific genes during cardiovascular development and cardiac disordersincluding cardiac hypertrophy. Emerging evidence suggests that in addition tofunctioning as muscle-specific transcription factors, members of the TEF familymay be key mediators of gene expression induced by hypoxia in endothelial cellsby virtue of its multidomain organization, potential for post-translationalmodifications, and interactions with numerous transcription factors, which representa cell-selective control mediator of nuclear signaling.
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