SW033291
SW033291
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Product Specification
| In vivo | In mice receiving a bone marrow transplant, SW033291 (10 mg/kg, i.p.) promotes hematopoietic recovery. In mouse models of colon and liver injury, SW033291 (10 mg/kg, i.p.) reduces the levels of colitis-associated inflammatory cytokines, protects mice from colitis, and promotes liver regeneration. |
| CAS Number | 459147-39-8 |
| Molecular Formula | C21H22N2OS3 |
| Purity | >98% |
| Molecular Weight | 414.61 |
| Target | 15-PGDH ,15-PGDH |
| Appearance | Powder |
| Synonym | SW033291,SW-033291,SW033291,SW 033291 |
| In vitro | In Vaco-503 cells, SW033291 (2.5 μM) decreases cellular 15-PGDH enzyme activity by 85%. |
| Description | SW033291 is a potent inhibitor of 15-PGDH enzyme with IC50 value of 1.5 nM and dissociation constant Ki app value of 0.1 nM. |
| Solubility | DMSO 83 mg/mL (201.16 mM) Ethanol 32 mg/mL warmed (77.55 mM) |
| Storage Temp. | store at -20° C for one year（Powder）； in DMSO or others solvent store at 2-4° C for two weeks, at -20° C for six months. |