STOML2 Mouse mAb

STOML2 (Stomatin-like protein 2) is an evolutionarily highly conserved membrane protein belonging to the stomatin family, widely expressed on the mitochondrial outer membrane and plasma membrane, where it participates in various biological processes including maintenance of membrane structure, ion channel regulation, and signal transduction. At the functional level, the most prominent role of STOML2 is to influence cellular metabolism through regulating mitochondrial morphology and function—it interacts with mitochondrial fusion proteins MFN1/2 and the fission protein DRP1, promoting mitochondrial fusion and maintaining normal cristae structure, thereby safeguarding oxidative phosphorylation efficiency and reducing reactive oxygen species production. Meanwhile, STOML2 also participates in regulating cellular pH and sodium ion balance by binding to and negatively modulating the activity of acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaCs). Furthermore, STOML2 is significantly overexpressed in various tumors (such as colorectal cancer, liver cancer, and breast cancer), where it promotes tumor cell proliferation, migration, invasion, and chemotherapy resistance through activating signaling pathways such as PI3K-AKT-mTOR or STAT3, and is closely associated with poor patient prognosis, making it a promising prognostic biomarker and therapeutic target in oncology. Importantly, STOML2 dysfunction is also associated with pathological processes including cardiac ischemia-reperfusion injury, lipid metabolism disorders, and neurodegenerative diseases, highlighting its significant status as a multifunctional protein under both physiological and pathological conditions.