1 1

STAT6 His&Strep Tag Protein, Human

STAT6 His&Strep Tag Protein, Human

Catalog Number: UA085004 Brand: UA BIOSCIENCE
Share:
Price:
$319.00 SGD
$319.00 SGD
Size:
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details

Product Details

Product Specification


Species Human
Synonyms STAT6C,STAT6B, interleukin-4 induced,IL-4-STAT,D12S1644
Accession P42226-1
Amino Acid Sequence

Met1-Trp847 with His&Strep Tag at the C-Terminus
Expression System Baculovirus-InsectCells
Molecular Weight

95-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & > 90% SEC-HPLC
Conjugation Unconjugated
Tag His Tag, Strep Tag
Physical Appearance Liquid
Storage Buffer

50mM Hepes,200mM NaCl,20%Glycerol,1mM DDT
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M. STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology. Pathol Res Pract. 2021 Jul;223:153477.
2.Chao H, Zheng L, Hsu P, He J, Wu R, Xu S, Zeng R, Zhou Y, Ma H, Liu H, Tang Q. IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation. JCI Insight. 2023 Mar 22;8(6):e157091.

Background

STAT6 (Signal Transducer and Activator of Transcription 6) is a transcription factor that plays a pivotal role in the cellular response to interleukin-4 (IL-4). It is activated through IL-4-induced tyrosine phosphorylation. Its primary function is to mediate most of IL-4's effects, including promoting cell survival by inducing the expression of the anti-apoptotic gene BCL2L1/BCL-X(L). To activate transcription, STAT6 requires interaction with coactivator proteins like p300 and CBP. A key physiological characteristic is its direct interaction with NF-κB, which underlies the synergistic transcriptional activation observed between the IL-4 and NF-κB signaling pathways. Clinically, its central role in IL-4-mediated responses makes it a molecule of interest in immune-related processes.

Picture

SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of STAT6 His&Strep Tag Protein, Human is more than 90% determined by SEC-HPLC.