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SHBG His Tag Protein, Human

SHBG His Tag Protein, Human

Catalog Number: UA106003 Brand: UA BIOSCIENCE
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$185 USD
$185 USD
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Product Details

Product Specification


Species Human
Accession P04278
Amino Acid Sequence

Leu30-His402, with C-His tag
Expression System HEK293
Molecular Weight

Predicted MW: 42.2 kDa Observed MW: 50 kDa
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

0.2M PBS, pH7.4.
Reconstitution

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage


12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to androgens and estrogens. SHBG is found in all vertebrates apart from birds. SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the level of SHBG. SHBG’s production is regulated under the influence of FSH on Sertoli cells, enhanced by insulin, retinol, and testosterone. The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > estradiol > estrone. SHBG levels are usually about twice as high in women than in men. In women, SHBG serves to limit exposure to both androgens and estrogens. Low SHBG levels in women have been associated with hyperandrogenism and endometrial cancer due to heightened exposure to androgens and estrogens, respectively. During pregnancy, due to activation of SHBG production in the liver by high estrogen levels, SHBG levels increase by five-fold to ten-fold.

Picture

SDS-PAGE

2μg（R: reducing conditions）