Measured in a cell proliferation assay using human M-07e cells, the EC50 for this effect is less than 1ng/ml.
SCF Protein, Mouse
SCF Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7, KL |
| Accession | P20826 |
| Amino Acid Sequence | Lys26-Ala189 |
| Expression System | E.coli |
| Molecular Weight | 18kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 100mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Physiol Rev. 2012 Oct;92(4):1619-49. doi:
10.1152/physrev.00046.2011 |
Background
Stem Cell Factor is also known as SCF,
kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7,
and is a cytokine that binds to the c-Kit receptor (CD117). Stem cell factors
perform their biological functions by binding to and activating the receptor
tyrosine kinase c-Kit. The human SCF gene encodes for a 273 amino acid
transmembrane protein, which contains a 25 amino acid N-terminal signal
sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane
domain, and a 36 amino acid cytoplasmic domain. Stem cell factor (SCF) has been
shown to stimulate the proliferation of myeloid, erythroid, and lymphoid
progenitor cells in bone marrow culture and has been shown to work synergically
with colony-stimulating factors.
Picture
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
