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Rat Anti-Mouse GITR Antibody (S-3837)

Rat Anti-Mouse GITR Antibody (S-3837)

Catalog Number: S0B8516 Application: FCM Reactivity: Mouse Conjugation: Unconjugated Brand: Starter
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Product Details

Product Specification


Host Rat
Antigen GITR
Synonyms Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; CD357; Gitr; Tnfrsf18
Location Cell membrane
Accession O35714
Clone Number S-3837
Antibody Type Rat mAb
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse splenocytes
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Ms

Background

GITR (glucocorticoid-induced TNF receptor, TNFRSF18/CD357) is a cell-surface receptor of the TNF-receptor superfamily that is constitutively expressed at high levels on regulatory T cells (Tregs) and is rapidly up-regulated on activated CD4⁺/CD8⁺ T cells and NK cells; engagement of GITR by its ligand GITRL (TNFSF18) on antigen-presenting cells delivers a costimulatory signal that activates the NF-κB pathway, enhances IL-2 and IFN-γ production, up-regulates the anti-apoptotic protein Bcl-xL, and thereby amplifies effector T-cell proliferation, cytokine secretion and cytotoxicity while transiently destabilizing FoxP3 and the suppressive function of Tregs, making GITR an attractive target for cancer immunotherapy.

Picture

FC

Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse GITR antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Rat IgG2b, λ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD45R/B220 - Pacific Blue Antibody separately.