Rat Anti-Mouse CD80 (B7-1) Antibody (S-3833)

CD80，also known as B7-1，is a co - stimulatory molecule expressed on antigen - presenting cells（APCs）such as dendritic cells，macrophages and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a co - stimulatory signal necessary for T cell activation，thereby promoting T cell proliferation and differentiation. Additionally，CD80 can also bind to CTLA - 4，an inhibitory receptor on T cells，which acts as a negative regulator of T cell activation. This binding can inhibit the immune response and maintain immune tolerance. Moreover，CD80 - CD28 interaction is involved in the regulation of various immune - related processes，including the formation of immunological synapses and the regulation of cytokine production.