Rat Anti-Mouse CD276 Antibody (MJ18)
Rat Anti-Mouse CD276 Antibody (MJ18)
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD276 |
| Synonyms | CD276 antigen; B7 homolog 3 (B7-H3); Costimulatory molecule; B7h3; Cd276 |
| Location | Membrane |
| Accession | Q8VE98 |
| Clone Number | MJ18 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B6817 |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD276 (B7-H3) is an immune checkpoint molecule belonging to the B7 family and encodes a type I transmembrane protein. It plays a role in regulating T cell-mediated immune responses. CD276 is highly expressed in various tumor cells and tumor-infiltrating immune cells, aiding tumor cells in evading immune surveillance and promoting tumor proliferation, metastasis, and treatment resistance. Additionally, CD276 is associated with cancer stem cell properties, and its high expression is linked to poor prognosis. Currently, several targeted therapies against CD276, including monoclonal antibodies, bispecific antibodies, antibody-drug conjugates (ADCs), and CAR-T cell therapies, are under development and in clinical trials, showing promising anti-tumor potential.
