Flow cytometric analysis of C57BL/6 mouse bone marrow labelling Mouse CD170 antibody at 1/2000 (0.1 μg) dilution/ (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD11b - Brilliant Violet 421™ Antibody separately.
Rat Anti-Mouse CD170 Antibody (S-R691)
Rat Anti-Mouse CD170 Antibody (S-R691)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD170 |
| Synonyms | Sialic acid-binding Ig-like lectin 5; Siglec-5; Sialic acid-binding Ig-like lectin F (Siglec-F; mSiglec-F); Siglecf; Siglec5 |
| Location | Membrane |
| Accession | Q920G3 |
| Clone Number | S-R691 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD170, also known as Siglec-5 or OBBP2, is a type I transmembrane glycoprotein and a member of the sialic acid-binding Ig-like lectin (Siglec) family. It is expressed on various immune cells, including monocytes, neutrophils, macrophages, and dendritic cells. This molecule is characterized by its ability to bind sialic acids, which are often found on the surface of cells. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain, which is involved in intracellular signaling and can inhibit the activation of immune cells. CD170 is involved in mediating sialic acid-dependent cell adhesion and plays a role in immune regulation. In addition, it has been implicated in immune evasion by certain pathogens, such as Group B Streptococcus.
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