Rat Anti-Human/Mouse TOX Antibody (S-4516)
Rat Anti-Human/Mouse TOX Antibody (S-4516)
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | TOX |
| Synonyms | Thymocyte selection-associated high mobility group box protein TOX; Thymus high mobility group box protein TOX; KIAA0808 |
| Location | Nucleus |
| Accession | O94900 |
| Clone Number | S-4516 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu, Ms |
Background
TOX protein is a transcription factor that plays a crucial role in the immune system. It is involved in the regulation of T cell differentiation and function, particularly in the development and maintenance of regulatory T cells (Tregs) which are essential for maintaining immune tolerance and preventing autoimmunity. Additionally, TOX has been implicated in the response of T cells to chronic antigen stimulation, such as in the context of chronic infections or cancer, where it may contribute to T cell exhaustion. Its expression and activity can influence the balance between effector and regulatory T cell populations, thereby having a significant impact on the overall immune response.
