Flow cytometric analysis of Human PBMC labelling CLEC4A antibody at 1/200 (1 μg) dilution (Right panel) compared with a Rabbit IgG Isotype Control (Left panel). Goat Anti-Rabbit IgG DyLight Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD11b - Brilliant Violet 421™ antibody separately.
Rabbit Anti-Human CLEC4A Antibody (S-2104-129)
Rabbit Anti-Human CLEC4A Antibody (S-2104-129)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | CLEC4A |
| Synonyms | C-type lectin domain family 4 member A; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor; CD367; CLECSF6; DCIR; LLIR |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q9UMR7 |
| Clone Number | S-2104-129 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CLEC4A (C-type lectin domain family 4 member A), also known as DCIR or CD367, is a type II transmembrane inhibitory receptor expressed mainly on dendritic cells and other myeloid cells; it contains an extracellular C-type lectin-like domain that binds glycan structures independent of calcium, a single transmembrane segment, and a cytoplasmic tail harboring an immunoreceptor tyrosine-based inhibitory motif (ITIM) which, upon ligand engagement, recruits phosphatases SHP-1/2 to down-regulate TLR signaling, suppress pro-inflammatory cytokine production, and maintain immune homeostasis, while also serving as an attachment factor for pathogens such as HIV-1.
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