R-Spondin1/RSPO1 Protein, Human (Cat#UA040554) maintains colorectal cancer organoid growth well during multiple passages and long-term culture processes.
R-Spondin1/RSPO1 Protein, Human类器官培养专用
R-Spondin1/RSPO1 Protein, Human类器官培养专用
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | R-spondin-1, Roof plate-specific spondin-1 (hRspo1) |
| Accession | Q2MKA7 |
| Amino Acid Sequence | Ser21-Ala263 |
| Expression System | CHO |
| Molecular Weight | 30-33, 37-38kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 2011 Jul 4;476(7360):293-7. |
Background
R-spondin 1 (RSPO1) is a secreted protein that belongs to the R-spondin family, which consists of four structurally related proteins (RSPO1-4) that act as ligands for the Wnt signaling pathway. RSPO1 plays a crucial role in regulating Wnt/β-catenin signaling by binding to the LGR4-6 receptors and enhancing the activity of Wnt ligands. This interaction leads to the stabilization of β-catenin and the activation of Wnt target genes involved in cell proliferation, differentiation, and stem cell maintenance. RSPO1 has been implicated in various developmental processes, including embryogenesis, tissue regeneration, and stem cell self-renewal. Dysregulation of RSPO1 signaling has been associated with several diseases, such as cancer and developmental disorders.
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Bioactivity
R-Spondin1/RSPO1 Protein, Human (Cat#UA040554) maintains lung cancer organoid growth well during multiple passages and long-term culture processes.
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
