WB result of PMP22 Recombinant Rabbit mAb
Primary antibody: PMP22 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: HeLa whole cell lysate 20 µg
Lane 2: SH-SY5Y whole cell lysate 20 µg
Secondary antibody: Goat Anti-Rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution Predicted MW: 18 kDa
Observed MW: 27 kDa
PMP22 Recombinant Rabbit mAb (S-754-145)
PMP22 Recombinant Rabbit mAb (S-754-145)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | PMP22 |
| Synonyms | Peripheral myelin protein 22; PMP-22; Growth arrest-specific protein 3 (GAS-3); GAS3 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q01453 |
| Clone Number | S-754-145 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, SH-SY5Y, mouse brain, PC-12 |
| Predicted Reactivity | Hr, Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
PMP22, or Peripheral Myelin Protein 22, is a protein that is primarily expressed in the compact myelin of the peripheral nervous system. It plays a crucial role in the formation and maintenance of the myelin sheath, which insulates nerve fibers and allows for efficient transmission of nerve impulse. Abnormalities in the PMP22 gene are responsible for a group of inherited peripheral neuropathies, including Charcot-Marie-Tooth disease type 1A (CMT1A), Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) and CMT1E. PMP22-related neuropathies are the most prevalent among the inherited neuropathies, and understanding their clinical presentations and genetic testing is essential for neurologists and geneticists dealing with inherited neuropathy patients.
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Western Blot
WB result of PMP22 Recombinant Rabbit mAb
Primary antibody: PMP22 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: mouse brain lysate 20 µg
Secondary antibody: Goat Anti-Rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution Predicted MW: 18 kDa
Observed MW: 27 kDa
WB result of PMP22 Recombinant Rabbit mAb
Primary antibody: PMP22 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: PC-12 whole cell lysate 20 µg
Secondary antibody: Goat Anti-Rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution Predicted MW: 18 kDa
Observed MW: 27 kDa
