Phospho-Met (Tyr1234/1235) Recombinant Rabbit mAb (S-3457)

Phospho-Met (Tyr1234/1235) refers to the activated form of the c-Met receptor tyrosine kinase, a critical transmembrane protein encoded by the MET proto-oncogene, wherein phosphorylation at tyrosine residues 1234 and 1235 within the intracellular kinase activation loop serves as a definitive molecular switch for its enzymatic activity. This specific dual phosphorylation event is induced upon binding of its primary ligand, hepatocyte growth factor (HGF), leading to conformational changes that stabilize the active kinase state, thereby facilitating downstream signal transduction through major pathways such as PI3K/Akt, RAS/MAPK, and STAT, which collectively regulate essential cellular processes including proliferation, survival, motility, and morphogenesis. Due to its pivotal role in tissue regeneration and embryonic development, as well as its frequent dysregulation in various malignancies where it drives tumor growth, invasion, and metastasis, Phospho-Met (Tyr1234/1235) is widely utilized as a specific biomarker in research and clinical diagnostics to monitor c-Met pathway activation and to evaluate the efficacy of targeted therapeutic inhibitors designed to block this oncogenic signaling axis.