Phospho-DRP1 (Ser637) Recombinant Rabbit mAb (S-5676)

Phospho-DRP1 (Ser637) refers to the phosphorylated form of Dynamin-related protein 1 at serine residue 637, a critical post-translational modification that serves as a key regulatory switch controlling mitochondrial fission and fusion dynamics. Unlike the activating phosphorylation at Ser616, phosphorylation at Ser637 is primarily mediated by Protein Kinase A (PKA) and acts as an inhibitory mechanism that reduces DRP1’s GTPase activity and prevents its recruitment to the mitochondrial outer membrane, thereby suppressing mitochondrial fragmentation and promoting organelle elongation. This specific phospho-site functions as a vital signaling node integrating cellular stress responses and metabolic cues, as its dephosphorylation by calcineurin or other phosphatases can rapidly reverse the inhibition to allow fission during apoptosis or mitosis, making Phospho-DRP1 (Ser637) an essential biomarker for assessing mitochondrial health, bioenergetic adaptation, and the pathophysiology of neurodegenerative and cardiovascular diseases linked to mitochondrial dysfunction.