Flow cytometric analysis of Human CD115 expression on human peripheral blood leukocytes. Human peripheral blood Leukocytes were stained with either PerCP-Cy5.5 Rat IgG1, κ Isotype Control (left panel) or PerCP-Cy5.5 Rat Anti-Human CD115 Antibody (right panel) at 5 μl/test, treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
PerCP-Cy5.5 Rat Anti-Human CD115 Antibody (S-R722)
PerCP-Cy5.5 Rat Anti-Human CD115 Antibody (S-R722)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD115 |
| Location | Cell membrane |
| Accession | P07333 |
| Clone Number | S-R722 |
| Antibody Type | Rat mAb |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood leukocyte |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PerCP-Cy5.5 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD115, also known as Colony-Stimulating Factor 1 Receptor (CSF1R) or M-CSF receptor (M-CSFR), is a 972-amino-acid cell-surface glycoprotein encoded by the CSF1R gene (c-FMS proto-oncogene) that belongs to the type III receptor tyrosine kinase family; it serves as a receptor for the cytokines CSF-1 and IL-34, and is highly expressed on monocyte-lineage cells and osteoclasts, mediating their survival, proliferation, differentiation, and motility through ligand-induced oligomerization and transphosphorylation, with mutations linked to myeloid malignancies and increased expression observed in Alzheimer’s disease microglia and breast carcinogenesis .
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