Flow cytometric analysis of CD46 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either PerCP-Cy5.5 Mouse IgG2a, k Isotype Control (left panel) or SDT PerCP-Cy5.5 Mouse Anti-Human CD46 Antibody (right panel) at 2 μl/test treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
PerCP-Cy5.5 Mouse Anti-Human CD46 Antibody (S-3061)
PerCP-Cy5.5 Mouse Anti-Human CD46 Antibody (S-3061)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD46 |
| Synonyms | Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; MCP; MIC10 |
| Location | Cell membrane |
| Accession | P15529 |
| Clone Number | S-3061 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Isotype Control | S0B80056 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.1 mg/ml |
| Conjugation | PerCP-Cy5.5 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 2μl per million cells in 100μl volume | Hu |
Background
CD46, also known as membrane cofactor protein (MCP), is a type I transmembrane glycoprotein expressed on almost all human nucleated cells that protects host tissues from complement-mediated injury by acting as a cofactor for factor I–mediated proteolytic inactivation of the complement fragments C3b and C4b, and also modulates adaptive immunity by driving IFN-γ–biased Th1 responses and subsequent IL-10–producing T-regulatory cell differentiation, while serving as a cellular receptor for multiple pathogens including measles virus, adenoviruses, HHV-6, and pathogenic Neisseria.
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