Flow cytometric analysis of Mouse CD11c expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with APC Rat Anti-Mouse I-A/I-E Antibody (S0B1677) and either PerCP-Cy5.5 Armenian Hamster Isotype Control (Left panel) or SDT PerCP-Cy5.5 Armenian Hamster Anti-Mouse CD11c Antibody (Right panel) at 5μl/test treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
PerCP-Cy5.5 Armenian hamster Anti-Mouse CD11c Antibody (N418)
PerCP-Cy5.5 Armenian hamster Anti-Mouse CD11c Antibody (N418)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Synonyms | Integrin alpha-X; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; Itgax |
| Location | Membrane |
| Accession | Q9QXH4 |
| Clone Number | N418 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PerCP-Cy5.5 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD11c, also known as integrin alpha X (ITGAX), is a ~150 kDa type I transmembrane glycoprotein that pairs non-covalently with the 95 kDa beta2 integrin CD18 to form the αXβ2 heterodimer (complement receptor 4, CR4), which mediates cell adhesion, migration, and phagocytosis by binding diverse ligands such as iC3b, fibrinogen, ICAMs, and denatured proteins; it is predominantly expressed on myeloid dendritic cells, tissue macrophages, activated monocytes, and some B-cell subsets, serving as a classic marker for conventional dendritic cells in both mice and humans, and plays crucial roles in immune surveillance, antigen presentation, and inflammatory responses while also being implicated in autoimmune diseases and serving as a therapeutic target in cancer immunotherapy.
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