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PE Rat Anti-Mouse CD182 Antibody (S-R718)

PE Rat Anti-Mouse CD182 Antibody (S-R718)

Catalog Number: S0B81211 Application: FCM Reactivity: Ms Conjugation: PE Brand: Starter
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Product Details

Product Specification


Host Rat
Antigen CD182
Location Cell membrane
Accession P35343
Clone Number S-R718
Antibody Type Rat mAb
Isotype IgG2a,k
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse bone marrow
Purification Protein G
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.09% sodium azide
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1μg per million cells in 100μl volume Ms

Background

CD182, also known as CXCR2 or IL-8 receptor beta, is a 67-70 kDa member of the G-protein-coupled receptor family with seven transmembrane regions. It is expressed on various cell types, including neutrophils, natural killer cells, T cell subsets, monocytes, endothelial cells, and others. CD182 plays a crucial role in mediating chemotaxis, cell activation, proliferation, and angiogenesis. It binds to chemokines such as IL-8, NAP-2, GCP-2, and GRO-alpha, -beta, and -gamma, which induce these biological effects. This receptor is also involved in neutrophil migration to sites of inflammation and is essential for the positioning of oligodendrocyte precursors in the developing spinal cord.

Picture

FC

Flow cytometric analysis of Mouse CD182 expression on C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow were stained with Brilliant Violet 421™ Rat Anti-Mouse CD11b Antibody and either PE Rat IgG2a, k Isotype Control (left panel) or SDT PE Rat Anti-Mouse CD182 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.