Flow cytometric analysis of TIM-3 expression on Human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with FITC Mouse Anti-Human CD56 Antibody and either PE Mouse IgG1, κ Isotype Control (left panel) or PE Mouse Anti-Human TIM-3 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
PE Mouse Anti-Human TIM-3 Antibody (F38-2E2)
PE Mouse Anti-Human TIM-3 Antibody (F38-2E2)
Price:
Regular price
$180 USD
Regular price
Sale price
$180 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | TIM-3 |
| Location | Cell membrane, Cell junction |
| Accession | Q8TDQ0 |
| Clone Number | F38-2E2 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B5756 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) is a transmembrane checkpoint receptor selectively expressed on interferon-γ-producing T cells, Tregs, and innate immune cells; engagement of its ligands (galectin-9, CEACAM1, HMGB1, phosphatidylserine) triggers inhibitory signaling that terminates Th1 responses, promotes T-cell exhaustion, and fosters tolerogenic dendritic cell activity, thereby serving as a key negative regulator of antitumor and antimicrobial immunity and representing an actionable target for cancer immunotherapy.
Picture
Picture
FC
