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PE Mouse Anti-Human CD226 Antibody (DX11)

PE Mouse Anti-Human CD226 Antibody (DX11)

Catalog Number: S0B80942 Application: FCM Reactivity: Hu Conjugation: PE Brand: Starter
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$160 USD
$160 USD
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Product Details

Product Specification


Host Mouse
Antigen CD226
Location Cell membrane
Accession Q15762
Clone Number DX11
Antibody Type Mouse mAb
Isotype Control S0B5756
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.09% sodium azide
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD226, also known as DNAX accessory molecule-1 (DNAM-1), PTA-1, or TLiSA1, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed on the surface of natural killer (NK) cells, T cells, B cells, monocytes, and platelets. CD226 plays a crucial role in mediating cell adhesion, particularly between platelets and megakaryocytic cells to vascular endothelial cells, and it is also involved in the maturation of megakaryocytic cells. Structurally, CD226 contains two immunoglobulin-like V-set domains and has multiple glycosylation sites in its extracellular region. Its ligands include CD155 (PVR) and CD112, which are widely expressed on various cell types, including tumor cells, making CD226 an important factor in immune responses against cancer. Additionally, genetic variants of CD226 have been associated with autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.

Picture

FC

Flow cytometric analysis of human CD226 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 Antibody and either PE Mouse IgG1, k Isotype Control (left panel) or SDT PE Mouse Anti-Human CD226 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.