2e5 of transient transfected anti- BCMA/TNFRSF17 ScFv CAR-293 cells were stained with 1ug PE-Labeled BCMA/TNFRSF17 His Tag Protein, Human, (Cat. No. UA011247) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). PE signal was used to evaluate the binding activity.
2e5 of transient transfected anti- BCMA/TNFRSF17 ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. D and E). Alexa Fluor® 488 signal was used to evaluate the binding activity.
PE-Labeled BCMA/TNFRSF17 His Tag Protein, Human
PE-Labeled BCMA/TNFRSF17 His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CD269,TNFRSF17,BCM,BCMA,TNFRSF13A,Herpes virus entry mediator A,Herpesvirus entry mediator A,HveA,Tumor necrosis factor receptor-like 2,TR2 |
| Accession | Q02223-1 |
| Amino Acid Sequence | Met1-Ala54 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 15-19kDa |
| Conjugation | PE |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Gene ID: 608, updated on 18-Aug-2023. |
Background
B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
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