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PE-Cy7 Mouse Anti-Human CD46 Antibody (S-3061)

PE-Cy7 Mouse Anti-Human CD46 Antibody (S-3061)

Catalog Number: S0B80835 Application: FCM Reactivity: Hu Conjugation: PE-Cy7 Brand: Starter
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$160 USD
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Product Details

Product Specification


Host Mouse
Antigen CD46
Synonyms Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; MCP; MIC10
Location Cell membrane
Accession P15529
Clone Number S-3061
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.1 mg/ml
Conjugation PE-Cy7
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.09% sodium azide
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 2μl per million cells in 100μl volume Hu

Background

CD46, also known as membrane cofactor protein (MCP), is a type I transmembrane glycoprotein expressed on almost all human nucleated cells that protects host tissues from complement-mediated injury by acting as a cofactor for factor I–mediated proteolytic inactivation of the complement fragments C3b and C4b, and also modulates adaptive immunity by driving IFN-γ–biased Th1 responses and subsequent IL-10–producing T-regulatory cell differentiation, while serving as a cellular receptor for multiple pathogens including measles virus, adenoviruses, HHV-6, and pathogenic Neisseria.

Picture

FC

Flow cytometric analysis of CD46 expression on human PBMCs (human peripheral blood mononuclear cells). Human PBMCs were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either PE-Cy7 Mouse IgG2a, k Isotype Control (left panel) or SDT PE-Cy7 Mouse Anti-Human CD46 Antibody (right panel) at 2 μl/test treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.