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PCSK9 His Tag(D374Y) Protein, Human

PCSK9 His Tag(D374Y) Protein, Human

Catalog Number: UA016063 Brand: UA BIOSCIENCE
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$1,085 USD
$1,085 USD
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Product Details

Product Specification


Species Human
Accession Q8NBP7
Amino Acid Sequence

Gln 31 - Gln 692 with His Tag at the C-Terminus
Expression System HEK293
Molecular Weight

15-25kDa&55-70kDa (Reducing)

Purity ＞95% by SDS-PAGE&HPLC
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4, 5% trehalose
Reference

1. Zhao, M., et al. (2025). PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression. Scientific Reports, 15, 6941.
2. Cunningham, D., et al. (2007). Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nature Structural & Molecular Biology, 14(5), 413-419.
3. Fasano, T., et al. (2009). Degradation of LDLR protein mediated by 'gain of function' PCSK9 mutants in normal and ARH cells. Atherosclerosis, 203(1), 166-171.

Picture

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).

SEC-HPLC

The purity of PCSK9 His Tag(D374Y) Protein, Human is more than 95% determined by SEC-HPLC.

ELISA

Immobilized Human LDL R, Fc Tag at 2μg/mL (100 μL/well) can bind PCSK9 His Tag(D374Y) Protein, Human (Cat.No.UA016063) with a linear range of 38-76 ng/mL.