PCDHB8 Recombinant Rabbit mAb (S-4950-10)

PCDHB8 (Protocadherin beta-8) is a calcium-dependent cell adhesion protein belonging to the clustered protocadherin beta subfamily within the non-classical cadherin superfamily. It is a single-pass type I membrane protein, with the human version comprising approximately 801 amino acids and having a theoretical molecular weight of about 87.6 kDa. Structurally, its extracellular region contains six cadherin repeat domains, each capable of binding three calcium ions. Among these, the Cadherin 1 through Cadherin 4 domains mediate homophilic trans dimerization with identical molecules on adjacent cell surfaces in a "head-to-tail" manner—Cadherin 1 of one molecule binds Cadherin 4 of the counterpart, and Cadherin 2 binds Cadherin 3—whereas the Cadherin 6 domain mediates promiscuous cis interactions with other protocadherins on the same cell membrane. Based on this molecular architecture, PCDHB8 is thought to participate in self/non-self discrimination between cells and thereby play a key role in the establishment and maintenance of specific neuronal connections in the central nervous system. At present, specific functional studies of this protein remain relatively limited, and its exact physiological role and significance in disease await further elucidation.