Flow cytometric analysis of Human CD41a expression on human peripheral blood platelets. Human peripheral blood platelets were stained with either Pacific Blue Mouse IgG1, κ Isotype Control (Black line histogram) or SDT Pacific Blue Mouse Anti-Human CD61 Antibody (Red line histogram) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Pacific Blue Mouse Anti-Human CD61 Antibody (S-R618)
Pacific Blue Mouse Anti-Human CD61 Antibody (S-R618)
Price:
Regular price
$222.00 SGD
Regular price
Sale price
$222.00 SGD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD61 |
| Synonyms | Integrin beta-3; Platelet membrane glycoprotein IIIa (GPIIIa); GP3A; ITGB3 |
| Location | Cell membrane, Synapse |
| Accession | P05106 |
| Clone Number | S-R618 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood platelets |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD61, also known as integrin beta-3 (ITGB3) or glycoprotein IIIa (gpIIIa), is a transmembrane protein encoded by the ITGB3 gene in humans. It is predominantly expressed on the surface of platelets and megakaryocytes. CD61 forms a crucial complex with CD41 (alphaIIb) to create the heterodimeric receptor gpIIb/IIIa, which is essential for platelet aggregation and thrombus formation. This receptor binds to fibrinogen, von Willebrand factor, and other extracellular matrix proteins, facilitating platelet adhesion and aggregation. In addition to its role in hemostasis, CD61 is also involved in various cellular processes, including cell adhesion, migration, and proliferation. It has been implicated in tumor progression, where it can influence tumor metabolism, immune microenvironment, and epithelial-to-mesenchymal transition.
Picture
Picture
FC
