Flow cytometric analysis of Human CD103 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 and either FITC Rat IgG1, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Human CD103 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Pacific Blue Mouse Anti-Human CD103 Antibody (Ber-ACT8)
Pacific Blue Mouse Anti-Human CD103 Antibody (Ber-ACT8)
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Product Details
Product Details
Product Specification
| Synonyms | Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD103; ITGAE |
| Location | Membrane |
| Accession | P38570 |
| Clone Number | Ber-ACT8 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD103, also known as integrin αEβ7, is a transmembrane heterodimer complex primarily expressed on tissue-resident memory T cells (T RM cells), regulatory T cells (Tregs), and certain dendritic cells. It binds to E-cadherin on epithelial cells, mediating lymphocyte adhesion and retention in tissues such as the skin, gut, and lungs. This interaction is crucial for immune surveillance and maintaining tissue integrity. CD103 expression is regulated by TGF-β, which enhances its ability to bind E-cadherin. In cancer research, CD103 is significant in tumor-infiltrating lymphocytes (TILs), influencing immune responses within tumors. Additionally, CD103 plays a role in cytotoxic T cell activation and effective tumor cell lysis.
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