p16INK4a Recombinant Rabbit mAb (S-2573-6)

p16INK4a is a 16 kDa cyclin-dependent kinase inhibitor encoded by the CDKN2A locus on chromosome 9p21 that specifically binds to and inactivates CDK4/6 complexes, thereby preventing phosphorylation of the retinoblastoma protein (pRb) and enforcing a G1 cell-cycle arrest that functions as a critical tumor-suppressive barrier against oncogenic stress; its expression rises sharply with aging and acts as a robust biomarker of cellular senescence across diverse tissues, while its frequent inactivation through deletion, mutation, or promoter hypermethylation is observed in numerous human cancers, underscoring its pivotal role in both aging-related pathophysiology and oncogenesis.