Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The EC50 for this effect is less than 5ng/mL.
NRG1/Heregulin-β1 Protein, Human
NRG1/Heregulin-β1 Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | NRG1-β1;Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF |
| Accession | Q02297-6 |
| Amino Acid Sequence | Ser177-Glu241 |
| Expression System | E.coli |
| Molecular Weight | 7-8kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS,pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Cell Rep. 2021 Sep 7;36(10):109656. |
Background
Heregulin-β also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases. And NRG1 isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury. The NRG1 receptors are membrane-spanning receptor tyrosin kinases of the ErbB family (ErbB1–4), of which the EGF receptor (ErbB1) is the most prominent representative.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
