Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The EC50 for this effect is less than 1ng/ml.
β-NGF Protein, Rat
β-NGF Protein, Rat
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Product Details
Product Details
Product Specification
| Species | Rat |
| Accession | P25427 |
| Amino Acid Sequence | Ser122-Gly241 |
| Expression System | E.coli |
| Molecular Weight | 14 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM HAc, pH2.9 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | PLoS One. 2024 Jun 14;19(6): e0303934. |
Background
Beta-Nerve Growth Factor (β-NGF), also known as NGFB, is a neurotrophic factor that plays a crucial role in the survival and differentiation of neurons, particularly in the peripheral and central nervous systems. It is a basic protein of 118 amino acids that acts as a trophic factor for sensory and sympathetic neurons of the peripheral nervous system, as well as for cholinergic neurons of the anterior basal forebrain. In rats, β-NGF is synthesized by neurons and non-neural cells and is involved in the maturation of various organs and the regulation of metabolic homeostasis. Pancreatic beta cells from rats synthesize and secrete NGF and express high-affinity TrkA receptors and low-affinity p75NTR neurotrophin receptors for NGF. β-NGF is also associated with the risk of post-traumatic stress disorder (PTSD), as trauma response leads to methylation of DNA nucleotides responsible for NGF expression
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
