Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The EC50 for this effect is 0.36-0.42 ng/ml.
β-NGF Protein, Human
β-NGF Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Beta-nerve growth factor, Beta-NGF |
| Accession | P01138 |
| Amino Acid Sequence | Ser122-Ala241 |
| Expression System | E.coli |
| Molecular Weight | 12-13 kDa (Non-Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Cureus. 2025 Jun 11;17(6):e85814. |
Background
β-NGF is the biologically active form of Nerve Growth Factor (NGF), a founding member of the neurotrophin family essential for neuronal development, survival, and function. Human β-NGF is a homodimeric protein composed of two identical 118-amino acid polypeptide chains. It is processed from a larger precursor (proNGF) through proteolytic cleavage.
β-NGF represents a fundamental neurotrophic factor with broad applications spanning from basic neuroscience research to clinical therapeutics. While recombinant human β-NGF and gene therapy approaches aim to harness its neuroprotective properties for neurodegenerative diseases, the most significant industrial success has been the development of anti-NGF monoclonal antibodies for chronic pain management. The dual role of NGF—promoting neuronal survival in development while mediating pathological pain in adulthood—highlights the complexity of targeting this pathway therapeutically.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
