Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The EC50 for this effect is less than 1.5ng/ml.
β-NGF Protein, Canine
β-NGF Protein, Canine
Price:
Regular price
$135 USD
Regular price
Sale price
$135 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Canine |
| Accession | A0A8I3PYI3 |
| Amino Acid Sequence | Ser122-Gly241 |
| Expression System | E.coli |
| Molecular Weight | 14 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM HAc, pH2.9 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Front Immunol. 2022 Jan 14:12:813300. eCollection 2021. |
Background
Beta-Nerve Growth Factor (β-NGF), in the context of canines, is a neurotrophic factor primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is also crucial for the survival of pancreatic beta cells and the regulation of the immune system. NGF binds with at least two classes of receptors: TrkA and LNGFR/p75NTR. β-NGF can promote bcl-2 gene expression by binding to the TrkA, which stimulates the proliferation and survival of the target neuron. High affinity binding between proNGF, sortilin, and p75NTR can result in either survival or programmed cell death (PCD). The expression of NGF is increased in inflammatory diseases where it suppresses inflammation. NGF appears to promote myelin repair. NGF is involved in various psychiatric disorders. Dysregulation of NGF signaling has also been linked to Alzheimer’s disease. NGF has been shown to play a role in cardiovascular diseases. Reduced plasma levels of NGF and BDNF have been associated with acute coronary syndromes and metabolic syndromes.
Picture
Picture
Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
