NaK-ATPase Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-1373-39)
NaK-ATPase Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-1373-39)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | NaK-ATPase |
| Synonyms | Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, ATP1A1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Melanosome |
| Accession | P05023 |
| Clone Number | S-1373-39 |
| Antibody Type | Recombinant mAb |
| Application | IF |
| Reactivity | Hu |
| Purification | Protein A |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| IF | 1:200 | Hu |
Background
NaK-ATPase, also known as the sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) or simply the sodium pump, is a crucial transmembrane protein found in the plasma membrane of animal cells. Utilizing the energy released from ATP hydrolysis, Na+/K+-ATPase actively transports Na+ ions out of the cell against their concentration gradient while simultaneously transporting K+ ions into the cell. This ion transport activity is essential for maintaining the electrochemical gradients across the cell membrane, contributing to the stability of the intracellular and extracellular environments. In addition to its role as an ion pump, Na+/K+-ATPase has signaling functions. It can serve as a receptor for certain hormones and drugs, participating in intracellular signaling cascades.
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Immunofluorescence
IF shows positive staining in paraffin-embedded human cervical squamous cell carcinoma. Anti- NaK-ATPase antibody was used at 1/200 dilution (Green) and incubated overnight at 4°C. Counterstained with DAPI (Blue). Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
IF shows positive staining in paraffin-embedded human lung adenocarcinoma. Anti- NaK-ATPase antibody was used at 1/200 dilution (Green) and incubated overnight at 4°C. Counterstained with DAPI (Blue). Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
