MTBR-Tau243 (225-242) Recombinant Rabbit mAb (SDT-2033-15)
MTBR-Tau243 (225-242) Recombinant Rabbit mAb (SDT-2033-15)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | MTBR-Tau243 |
| Synonyms | microtubule-binding region containing residue 243 |
| Immunogen | Synthetic Peptide |
| Accession | P10636-8 |
| Clone Number | SDT-2033-15 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ELISA, Competitive ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against Tau peptide (aa225-243), it shows good binding ability with Tau peptide (aa225-242). |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
MTBR-Tau243 is a segment of the tau protein located within its microtubule-binding region (MTBR), specifically spanning the tau microtubule-binding region containing residue 243. This protein fragment has garnered significant attention as a specific biomarker for tau tangle pathology in Alzheimer's disease. Research has shown that MTBR-Tau243 levels in cerebrospinal fluid (CSF) and plasma are closely correlated with the presence and progression of neurofibrillary tangles, which are a hallmark of Alzheimer's. Unlike other tau biomarkers such as phosphorylated tau species, which are more related to amyloid plaques, MTBR-Tau243 is strongly associated with tau aggregates and cognitive impairment. Its detection in body fluids can help distinguish Alzheimer's disease from other neurodegenerative disorders and may serve as a valuable tool for monitoring disease progression and evaluating the efficacy of tau-targeted therapies.
