MSLN/Mesothelin (296-580) His Tag Protein, Human
MSLN/Mesothelin (296-580) His Tag Protein, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | MPF |
| Accession | Q13421-1 |
| Amino Acid Sequence | Glu296-Gly580, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 36-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Mesothelin (MSLN) is a cell surface-bound, glycosylphosphatidylinositol (GPI) anchored protein, whose normal expression is restricted to the mesothelial cells of the pleura, pericardium, peritoneum, and tunica vaginalis in men, whereas very low MSLN expression (trace amounts) has also been observed in the epithelial lining of the ovaries, fallopian tubes, and rete testis. Mesothelin (MSLN) is a tumor differentiation antigen normally restricted to the body’s mesothelial surfaces, but significantly overexpressed in a broad range of solid tumors. For this reason, MSLN has emerged as an important target for the development of novel immunotherapies.
Picture
Picture
SDS-PAGE
ELISA
Immobilized MSLN/Mesothelin (296-580) His Tag, Human (Cat. No. UA010166) at 2.0μg/mL (100μL/well) can bind Anti-Human MSLN Monoclonal Antibody (Amatuximab) with EC50 of 1.56-1.89ng/mL.
